Incidence, risk factors, and severity of clinical manifestations of skin vasculitis in patients with HCV- and HCV/HIV-infection

Introduction. Several viruses including hepatitis C virus (HCV) and human immunodeficiency (HIV) can induce vasculitis. Aim. We aimed to study the incidence, risk factors, severity of skin vasculitis in patients with HCV HCV/HIV coinfection. Patients Methods. T he group included 331 (254 77 coinfection) referred a specialized hepatology center for antiviral therapy infection. Results. Skin was found 21% (95% CI: 17–25%) cases, n = 69/331. observed 20% infected 15–25%) 25% HIV/HCV co-infected CI; 16–35%), χ 2 0,892, р 0,345. Most had cryoglobulinemia (94%, 47/50), meanwhile, patients, 63% cases ( 12/19), 10.568, 0.001. Multiple regression analysis showed that related (OR 6,928, 95% 3.245–14.790, < 0.001), liver cirrhosis 2.015, 1.062–3.824, 0.032), duration overt infection 1.057, 1.021–1.094, 0.002), age 1.029, 1.002–1.057, 0.033) inversely plasma alanine transaminase 0.433, 0.229–0.820, 0.010). The statistical model normalized gender, HIV-positivity bilirubin levels, equation constant 4.398 p 0.001). intensity rashes comparable 6.741, 0.081), highly correlated cryoglobulin levels both r 0.788, 0.909, Conclusion. 20–25% among co-infection. Cryoglobulinemia main factor associated vasculitis, lesions closely levels.